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3-7 Jun 2019 Gif-sur-Yvette (France)
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Speakers & Trainers
MAIN COORDINATOR
Paloma Fernández Varela
(paloma.fernandez-varela@i2bc.paris-saclay.fr)
CNRS Research Engineer at the I2BC at Gif-sur-Yvette, she works at the Structural Biochemistry of Microtubules, Kinesins and their Cargos team in the Biochemistry, Biophysics and Structural Biology (B3S) department. She focuses on molecular mechanisms of autoinhibition and activation of kinesin motors by cargo recruitment using structural biology and biophysics approaches. She is also involved in the structural studies of tubulin-antimitotic inhibitors complexes. In addition she works as technological manager of the Macromolecular Interactions Platform (PIM) at the laboratory, being in charge of new technologies as MicroScale Termophoresis (MST) and switchSENSE.
SPEAKERS AND TRAINERS
Bruno Baron
Research Engineer at the Molecular Biophysics platform (PFBMI) at the Institut Pasteur, Paris. He is in charge of the spectroscopic line with circular dichroism device, stationary phase and stopped-flow fluorimetry, thermophoresis. The responsibility includes the training of new users, the maintenance and know-how of material, the understanding of the technology allowing the monitoring of short, medium and long term interaction with researchers, beginners or experts who need to complete their studies by biophysical measurements.
Guillaume Bec
(Guillaume.Bec@ibmc-cnrs.unistra.fr)
CNRS Research Engineer at the Structure and dynamics of biomolecular machines team at Strasbourg.The team is focusing on biophysical characterization of nucleic acid interactions. He is in charge of chromatographic and crystallographic facilities, and more recently involved in characterization of interactions using the switchSENSE technology.
Sébastien Brûlé
Research Engineer at the Molecular Biophysics platform (PFBMI) at the Institut Pasteur, Paris. He has set up a new service that allows you to obtain a full qualitative analysis (QC) of your purified proteins and to help you to identify conditions in which these proteins are best behaved.
Jean-Baptiste Charbonnier
(jb.charbonnier@i2bc.paris-saclay.fr)
CEA Researcher at the I2BC at Gif-sur-Yvette, he co-heads the team Nuclear Envelope and DNA repair in the B3S department. He focuses on molecular mechanisms related to DNA repair pathway and carcinogenesis using structural biology and biophysics approaches. In collaborations with biologists, the team aims at improving clinical interpretation of mutations on DNA damage factors associated with disease and at identifying new compounds inhibiting protein-protein interactions to improve treatment efficiency. The team uses crystallography, NMR, cryoEM to determine the atomic structures of DNA repair machineries. Biophysical methods including innovative methods like switchSENSE are also central in the team to analyze the protein interactions with DNA, protein, peptides and small molecules.
Christine Ebel
CNRS senior Scientist at the Institut de Biologie Structurale IBS at Grenoble, her research interests are centred on solution studies of complex systems. She has contributed to understanding molecular adaptation to extreme saline conditions, protein solvation and stabilization as well as strong and weak protein-protein interactions and protein crystallization. She is also involved in the characterisation of interactions of protein-sugar. She is now strongly involved in the field of membrane proteins. More particularly she developed new protocols for the characterization of their interactions in solution using hydrodynamics methods. She is evaluating new surfactants (amphiphilic polymers and fluorinated surfactants) for their structural characterization. She specializes in the biophysical methods used to further her research interest, in particular neutron scattering and analytical ultracentrifugation. She is responsible of the Analytical Ultracentrifugation (AUC) and of the Size exclusion chromatography – light scattering (PAOL) platforms, which are INSTRUCT (European) facilities.
Patrick England
Head of the Molecular Biophysis Facility ((PFBMI) at the Institut Pasteur, Paris. Chair of ARBRE-MOBIEU pan-european network is Molecular Scale Biophysics.
Eric Ennifar
(E.Ennifar@ibmc-cnrs.unistra.fr)
CNRS Senior Scientist at the Institut de Biologie Moléculaire et Cellulaire (IBMC) in Strasbourg, head of the group "Dynamics and Structure of Biomolecular Machines". His research interest are focused on the characterization of the HIV-1 Reverse Transcriptase and the ribosome machinery. His team is combining structural data with kinetics and thermodynamics using various biophysical approaches. He's also interested into methodological improvements and was involved into the development of the RIP-phasing in Xray crystallography or the kinITC in microcalorimetry.
Julie Ménétrey
(julie.menetrey@i2bc.paris-saclay.fr)
CNRS Researcher at the I2BC at Gif-sur-Yvette (France), she co-heads the Structural Biochemistry of Microtubules, Kinesins and their Cargos team in the Biochemistry, Biophysics and Structural Biology (B3S) department. She is particularly interested in characterizing the structural basis of cargo/adaptor protein recruitment by cytoskeletal motors, especially those from the kinesin superfamily to better understand their mode of recognition, as well as their impact in the motor regulation in the axonal transport in normal or pathological contexts. Her team uses crystallography to determine the atomic structures of these motors and their cargos, as well as biophysical methods to analyze their interactions in solution. Recently, she has been investigating the mode of binding of two structurally unrelated adaptor families, the JIP1/2 and JIP3/4 scaffolds by the kinesin1.
Philippe Minard
(philippe.minard@i2bc.paris-saclay.fr)
University Profesor at UPSud, he leads the Modelisation and Protein Enginery team in the Biochemistry, Biophysics and Structural Biology (B3S) department at the I2BC.
Magalie Niçaise-Aumont
(magali.aumont-nicaise@i2bc.paris-saclay.fr)
CNRS Research Engineer at the I2BC at Gif-sur-Yvette, she works as technological manager of the Macromolecular Interactions Platform (PIM) at the laboratory, being in charge of the microcalorimetry and SPR equipment.
Bertrand Raynal
Research Engineer at the Molecular Biophysics platform (PFBMI) at the Institut Pasteur, Paris. He is in charge of the “hydrodynamic characterization of macromolecules” section.
Alain Roussel
(Alain.Roussel@afmb.univ-mrs.fr)
Host-pathogen interactions team leader at AFMB, Marseille.
Terence Strick
Molecular motors and machines team leader at the IBENS, Paris.
David Stroebel
CNRS Research Engineer at the IBENS, Paris. He is manager of the Proteins Engineering platform at the laboratory.
Stephan Uebel
Head of the Microchemistry Core Facility, MPI of Biochemistry, Martinsried, Germany. Selected Publications: Broberg P., Fehniger T., Marko-Varga G. and Uebel S. (2005). “Elastin peptide fingerprints and analysis methods for MMP-12 related to COPD.“ EP 1 668 372 B1 and WO 2005/029090. Uebel S. and Tampé R. (1999). “Specificity of the proteasome and the TAP transporter.“ Curr Opin Immunol. 11, 203-208. Uebel S., Kraas W., Kienle S., Wiesmüller K.H., Jung G. and Tampé R. (1997). “Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries.“ Proc Natl Acad Sci U S A 94, 8976-8981.
Adrián Velázquez-Campoy
ARAID Research Scientist - Institute BIFI - University of Zaragoza (Spain). Selected Publications: Velazquez-Campoy A, Vega S, Sanchez-Gracia O, Lanas A, Rodrigo A, Kaliappan A, Hall MB, Nguyen TQ, Brock GN, Chesney JA, Garbett NC, Abian O. (2018). Thermal liquid biopsy for monitoring melanoma patients under surveillance during treatment: A pilot study. Biochim Biophys Acta Gen Subj. 1862(8):1701-1710. Neira JL, Hornos F, Cozza C, Cámara-Artigas A, Abián O, Velázquez-Campoy A. (2018). The histidine phosphocarrier protein, HPr, binds to the highly thermostable regulator of sigma D protein, Rsd, and its isolated helical fragments. Arch Biochem Biophys. 639:26-37. Claveria-Gimeno R, Lanuza PM, Morales-Chueca I, Jorge-Torres OC, Vega S, Abian O, Esteller M,Velazquez-Campoy A. (2017). The intervening domain from MeCP2 enhances the DNA affinity of the methyl binding domain and provides an independent DNA interaction site. Sci Rep. 7:41635. Velazquez-Campoy A, Sancho J, Abian O, Vega S. (2016) Biophysical Screening for Identifying Pharmacological Chaperones and Inhibitors Against Conformational and Infectious Diseases. Curr Drug Targets. 17(13):1492-505.
Christophe Velours
(christophe.velours@i2bc.paris-saclay.fr)
CNRS Engineer at the I2BC at Gif-sur-Yvette, he works as technological manager of the Macromolecular Interactions Platform (PIM) at the laboratory, being in charge of the AUC-FDS and SEC-MALS equipment.
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